Figure 2
Figure 2. Outcome from CR. (A) OS from CR. Events accounting for overall survival were 97 deaths in the 164 randomized patients compared with 40 deaths in the 53 patients noneligible for R2 randomization (P < .001 by the log-rank test) and 9 deaths in the 19 patients who refused R2 randomization (P = .71 by the log-rank test). (B) OS from CR according to the postremission randomization. Events accounting for overall survival were 53 deaths in the intensive arm compared with 44 deaths in the ambulatory arm (P = .03 by stratified Cox). (C) DFS according to the postremission randomization. Events accounting for disease-free survival were 59 relapses and 4 deaths in first complete remission in the intensive arm compared with 58 relapses and no deaths in first complete remission in the ambulatory arm (P = .04 by stratified Cox). Among the 4 deaths in first complete remission, 3 occurred during the neutropenic period after intensive consolidation (2 pulmonary infections, 1 septic shock), and 1 occurred later and was probably not related to AML therapy (rapid development of a lung carcinoma).

Outcome from CR. (A) OS from CR. Events accounting for overall survival were 97 deaths in the 164 randomized patients compared with 40 deaths in the 53 patients noneligible for R2 randomization (P < .001 by the log-rank test) and 9 deaths in the 19 patients who refused R2 randomization (P = .71 by the log-rank test). (B) OS from CR according to the postremission randomization. Events accounting for overall survival were 53 deaths in the intensive arm compared with 44 deaths in the ambulatory arm (P = .03 by stratified Cox). (C) DFS according to the postremission randomization. Events accounting for disease-free survival were 59 relapses and 4 deaths in first complete remission in the intensive arm compared with 58 relapses and no deaths in first complete remission in the ambulatory arm (P = .04 by stratified Cox). Among the 4 deaths in first complete remission, 3 occurred during the neutropenic period after intensive consolidation (2 pulmonary infections, 1 septic shock), and 1 occurred later and was probably not related to AML therapy (rapid development of a lung carcinoma).

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