Profiling of the TCRB-MYB cases by large-scale gene expression analysis. (A) Heat map representation of the hierarchical clustering of genes and samples using expression values for genes expressed differentially between the 4 TCRB-MYB cases and the SIL-TAL1, TLX1, and TLX3 cases (gene list in Table S1). One thymus sample and 4 T-cell lines are also included in the analysis. Cytogenetic/genomic annotations are as follows: Y indicates TCRB-MYB; L, TLX3; E, TLX1; and S, SIL-TAL1. Oncogenic groups: Y indicates TCRB-MYB; H, HOX-related; T, TAL-related; and c, cell lines.³⁸  Oncogene expression levels are shown as follows: TAL1 positive indicates range from 1 to 6; −, not analyzed; others are negative. LMO1 and LMO2: P indicates positive; −, not analyzed; others are negative. Data were normalized as described³⁸  and redundant probe sets were masked. The 4 TCRB-MYB cases (boxed in pink) are included in a cluster of cases indicated in blue, together with 3 cell lines (CCRF-CEM, Jurkat, and HSB2), the normal thymus sample, and a SIL-TAL case (TL29). Representative genes from the 3 major clusters are shown, and ectopic genes are indicated in red. (B) Average expression (± SD) of the genes that characterize the TCRB-MYB and cell line cluster. This cluster is specifically enriched in genes linked to cell cycle, cell proliferation, and mitosis, according to Gene Ontology (GO) terms (Table S2).