Features of the different DNA methylation groups. Bar plot of the different DNA methylation subsets showing the percentage of (A) genes containing and lacking PcG marks in ESCs and (B) genes with 1, 2, or 3 PcG marks. These analyses (A,B) show that the meL/umC and the dmeL/umC groups are highly and moderately enriched for PcG target genes in ESCs, respectively, compared with the umL/umC and meL/meC groups. Furthermore, the meL/umC group was highly enriched for PcG target genes containing all 3 PcG marks. (C) Comparison of the degree of enrichment of EED, SUZ12, and 3mK27 target genes in meL/umC and dmeL/umC. This analysis shows that the meL/umC group is highly enriched for PcG target genes containing EED compared with the dmeL/umC group. (D) Bar plot showing the percentage of promoter subtypes according to their CpG content (the P value refers to a global test) in the different DNA methylation subsets. This analysis demonstrates that genes de novo methylated in lymphomas (meL/umC and dmeL/umC) have promoters with mostly high CpG content. In contrast, genes methylated in a tissue-specific manner (meL/meC) have promoters with mostly low CpG content.