Treatment with HepIII protects implanted bones from osteolysis. At the termination of the experiment, implanted human bones were excised and imaged by microcomputed tomography (microCT). Shown are the three-dimensional reconstructions of the bones (sliced longitudinally through the midpoint of each specimen) injected with cells from patient 4 followed by treatment of the animal with either PBS (excessive bone resorption is seen) or HepIII (no bone resorption is observed, trabecular bone is intact). The areas of increased osteoclastic bone resorption in the PBS-treated sample are indicated by arrowheads. Note the appearance of the blue background behind the bone from the PBS-treated sample, indicative of resorption through the entire specimen. Scale bar equals 1 mm.