American Society of Hematology

Figure 5

Effect of dexamethasone on oxidative platelet particle formation induced by Ab, PMA, Ca2+ ionophore, or 12(S)-HETE. (A) Platelet particle formation. C indicates control buffer; Ci, control plus dexamethasone in the absence of agonist; Agn, agonists Pt IgG (patient IgG), PMA, or Ca-Ion (Ca2+ ionophore) in the absence and presence of dexamethasone 15 minutes prior to and then 4 hours after incubation of agonists at 37°C (n=5). (B) Platelet oxidation of oxidative fluor, DCFH. HETE refers to 12(S)-HETE (n=5). SEM is given.

Effect of dexamethasone on oxidative platelet particle formation induced by Ab, PMA, Ca²⁺ ionophore, or 12(S)-HETE. (A) Platelet particle formation. C indicates control buffer; Ci, control plus dexamethasone in the absence of agonist; Agn, agonists Pt IgG (patient IgG), PMA, or Ca-Ion (Ca²⁺ ionophore) in the absence and presence of dexamethasone 15 minutes prior to and then 4 hours after incubation of agonists at 37°C (n=5). (B) Platelet oxidation of oxidative fluor, DCFH. HETE refers to 12(S)-HETE (n=5). SEM is given.

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