Figure 6
Figure 6. LRAP mRNA is stabilized in REC-1 after NMD inhibition. (A) Normalized signals generated by GCOS for LRAP were log2 transformed and plotted for all cell lines and treatments (mock, □; E, ▩; E + A, ■). (B) The LRAP induction ratios (IRs) for each cell line were plotted together with the LRAP stabilization ratio (SR) in REC-1 (E, ▩; E + A, ■). (C) Schematic view of the LRAP splicing identified in REC-1 (LRAPS2) together with the normal variant (LRAP) and with a previously reported splicing (LRAPS). PTCs are labeled with asterisks. (D) Identification in primary MCLs of the LRAP splicing described in REC-1 emetine-treated cells.

LRAP mRNA is stabilized in REC-1 after NMD inhibition. (A) Normalized signals generated by GCOS for LRAP were log2 transformed and plotted for all cell lines and treatments (mock, □; E, ▩; E + A, ■). (B) The LRAP induction ratios (IRs) for each cell line were plotted together with the LRAP stabilization ratio (SR) in REC-1 (E, ▩; E + A, ■). (C) Schematic view of the LRAP splicing identified in REC-1 (LRAPS2) together with the normal variant (LRAP) and with a previously reported splicing (LRAPS). PTCs are labeled with asterisks. (D) Identification in primary MCLs of the LRAP splicing described in REC-1 emetine-treated cells.

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