Coordination of the cellular iron-acquisition pathway with mitochondrial PPIX formation and ISC assembly through modulation of IRP1 and IRP2 RNA binding affinities. Illustration by Jean-Pierre Laigneau.

Coordination of the cellular iron-acquisition pathway with mitochondrial PPIX formation and ISC assembly through modulation of IRP1 and IRP2 RNA binding affinities. Illustration by Jean-Pierre Laigneau.

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