AMN107 bound to the kinase domain of Abl. The ribbon diagram depicts the kinase domain of Abl (shown in gray) with AMN107 (shown as a transparent surface with its skeleton highlighted) bound within the ATP pocket, and with different point mutants highlighted to show their locations within the kinase domain. The side chains of the mutated residues are color-coded according to the color scheme used in Figure 1, such that E255K is red, Y253H/C is purple, and so on.