Pharmacodynamic data. (A) Platelet response in healthy male subjects following oral dosing with eltrombopag (once per day) for 10 days. Increases are apparent at 30, 50 and 75 mg. Values in graph indicate mean and 1 SD. (B) Kinetics of platelet response in healthy male subjects following 10 days oral dosing of 75 mg eltrombopag. The platelet number began rising at 5 days and peaked at day 15. Values in graph indicate mean and 1 SD.