Figure 6
![Figure 6. HK2 is a transcriptional target of LMP1 and is overexpressed in HRS cells. (A) Ectopic expression of LMP1 in L428 cells up-regulated the expression of HK2 (mRNA [left] and protein [right]). (B) Immunohistochemistry was used to study the expression of HK2 in primary HL. (Top) Low-level HK2 expression in germinal center (GC) and mantle zone (MZ) B cells of normal tonsil. (Middle, bottom) Strong staining of HK2 in HRS cells (arrow). Images were acquired using a Zeiss Photomicroscope II (Zeiss UK) equipped with a Nikon Coolpix990 camera and using Corel Paint Shop Pro v.10 software. All images were acquired using a 60 ×/1.4 NA oil-immersion objective lens.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/6/10.1182_blood-2006-05-020545/4/zh80060709540006.jpeg?Expires=1722441825&Signature=xdBIxzjZtLzfwK6m4ijUkrPWV-jIgDZhCRKKryS3Gfo~LpsnE1aFrKkpMqJlAKADBupS42oHnACgWxbfbcFfz6Ba6O8nZkvz-TEJznolqO9fKu2G1JP9VqB5fFVfadjBeHWp0vq4r0xAwwQc-U1gQuHecLBXxbUHOOy-v9~JukJsC~g-HDbUVEDACQbBHbh5EJwgoX4lfnHO9Xt06-PZeULuUWUcNPnho6tdAsCgQfMowrBFqMD2Uy-UwL2Z3FUSckBDrSZwQA3wwJjFg42WQOWLE1p8CHL~H2E~BGD3~Erc0yqW1VH-wBnl3-d3yw3QQAldQySwKKOM1HumAeimtA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
HK2 is a transcriptional target of LMP1 and is overexpressed in HRS cells. (A) Ectopic expression of LMP1 in L428 cells up-regulated the expression of HK2 (mRNA [left] and protein [right]). (B) Immunohistochemistry was used to study the expression of HK2 in primary HL. (Top) Low-level HK2 expression in germinal center (GC) and mantle zone (MZ) B cells of normal tonsil. (Middle, bottom) Strong staining of HK2 in HRS cells (arrow). Images were acquired using a Zeiss Photomicroscope II (Zeiss UK) equipped with a Nikon Coolpix990 camera and using Corel Paint Shop Pro v.10 software. All images were acquired using a 60 ×/1.4 NA oil-immersion objective lens.
