IVIG effects on the time course of MWReg30-mediated thrombocytopenia in mice after continuous intraperitoneal infusion of antiplatelet monoclonal antibody MWReg30. MWReg30 was administered by intraperitoneal infusion (0.99 μg/d × 7 days). IVIG was given by intraperitoneal bolus injection at 96 hours. Platelet counts were obtained using a Cell-Dyn 1700 multiparameter hematology analyzer. Symbols represent the sham control group and IVIG treatment groups (n = 5 mice/group): sham control group (▾), saline (•), 0.4 g/kg (▪), 1 g/kg (♦), 2 g/kg (▴). Error bars represent the standard deviation. IVIG attenuated MWReg30-mediated thrombocytopenia in a dose-dependent manner. Treatment differences were statistically significant (P < .001).