MM^High CD8⁺ T cells from HIV⁺ patients are highly sensitive to apoptosis. (A) Representative plots showing the gating strategies for lymphocytes, and histograms showing MM and annexin V positivity in total CD8⁺ T cells after culturing PBMCs from an HIV⁺ patient for 14 hours in the absence or presence of anti-CD95/Fas antibody. Apoptosis was measured in MM^High and MM^Low CD8⁺ T cells by annexin V staining. (B) Pooled data showing the percentage (%) of annexin V⁺ CD8⁺ T cells in MM^High and MM^Low CD8⁺ T cells from HIV⁺ individuals (n = 9). Bars depict means ± SE. The P values were calculated using Student t test.