70-gene risk score at diagnosis and relapse predicts postrelapse survival. (A) 70-gene risk score in paired diagnostic (blue) and relapse (red) samples of 51 patients from the training cohort. The gene expression risk score is indicated to the left. Sample pairs are order from left to right based on lowest baseline score. (B) Kaplan-Meier plots of postrelapse survival of the 3 groups defined by low risk both at diagnosis and relapse (Low-Low), low risk at diagnosis and high risk at relapse (Low-High), and high risk at both time points (High-High).