Risk group distribution and survival analyses in the test cohort. (A) Test cohort frequencies for the ratio of the mean of the log₂ up-/down-regulated genes. The cutoff for high risk was determined by independent clustering of the log₂ ratio. The training and validation sets have a similar distribution for this expression summary of the 70 genes, including similar cutoffs for high risk and similar proportions clustered into the high-risk group. Kaplan-Meier estimates of (B) EFS and (C) OS between molecular risk groups in the test cohort.