Figure 5
Hypoxia induces BMP4 expression and alters the response of stress BFU-Es to BMP4 and SCF. (A) Spleen cells were grown for 24 hours at 20% or 2% O2. Expression of BMP4 mRNA was measured by RT-PCR. (B) Spleen cells were plated in methylcellulose media containing Epo and grown for the indicated times in 20% or 2% O2. *P < .05, **P < .01, ***P < .005 for the indicated comparisons.
