Figure 2
![Figure 2. sIgM-mediated signal responses in CLL subgroups. The [Ca2+]i response to sIgM cross-linking was determined for 112 patients with CLL. The percentage of cells responding in subgroups defined by (A) somatic mutational status, (B) CD38 expression, (C) ZAP-70 expression status, and (D) sIgM MFI was assessed. Significance of differences was derived from the Mann-Whitney test (2-tailed, 95% CI). The dotted line at 5% shows the cutoff used to define signaling status as positive or negative. For sIgM, the median MFI of all the samples in the cohort was determined to be 50. sIgMhi samples were those with an MFI greater than 50, whereas sIgMlo samples had an MFI below 50. Horizontal bars indicate median values.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/10/10.1182_blood-2006-11-056648/4/zh80100701020002.jpeg?Expires=1724243644&Signature=mKLJSeXufVjg9lsQPbLxnwrih4YdgZi4nIPW-NVT-P9taP6~pBeykDrTDFEp1yT99NdhGgxzV44eHJSjCufun8FObZUhty59zQBXf21wv2nkFdYA-wfxdXTCuvQhKqVpNjZKxqAWsc94xwkof2znjRIoayPNytaUzh3cE0K82eleQS~gZwbjF8ms7NEvRDqdnKjzwATbygXOeq198M0Zaq7NFYkzowlnlrX31PoRGjdth5H~ZpB-GPis2yj-WYE7RhuhTj1c6Db5lNIKV~1~nVVkgziwWragVBSBOVFTvfeEhZeQlyQbyZHpdaVP~~Zl9PAY4qqSOSP6jKRm7q0Tfg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
sIgM-mediated signal responses in CLL subgroups. The [Ca2+]i response to sIgM cross-linking was determined for 112 patients with CLL. The percentage of cells responding in subgroups defined by (A) somatic mutational status, (B) CD38 expression, (C) ZAP-70 expression status, and (D) sIgM MFI was assessed. Significance of differences was derived from the Mann-Whitney test (2-tailed, 95% CI). The dotted line at 5% shows the cutoff used to define signaling status as positive or negative. For sIgM, the median MFI of all the samples in the cohort was determined to be 50. sIgMhi samples were those with an MFI greater than 50, whereas sIgMlo samples had an MFI below 50. Horizontal bars indicate median values.
