Dex suppresses LPS-mediated inflammatory gene expression. (A) Effect of Dex on LPS-mediated induction of TNF-α and IL-6 in control (□) and MGRKO (▪) macrophages. Data are shown as mean ± SEM; n = 5; *P < .01 compared with treatment group without Dex in control macrophages. (B) Effect of Dex on LPS-mediated induction of COX-2. Representative of 3 independent experiments.