GS patient displays normal ADCC and CD16 activation, but lacks CTL activity or NKp30-dependent lysis. (A) HFFs were infected with CMV and incubated with or without anti-CMV sera. The effector-to-target ratios are indicated. Specific lysis is shown from 1 of 2 experiments performed. (B) P815 target cells were incubated with anti-CD3 mAb to redirect CTL cytotoxicity. Lysis assays were performed as above and the effector-to-target ratios are indicated. One of 2 experiments is shown. (C-D) P815 cells were incubated either with anti-CD16 mAb (C) or with anti-NKp30 (D) to redirect NK cytotoxicity. Effector cells were then added in the indicated E/T ratios. Lysis assays were performed as before. One of 3 experiments is shown.