AML1/ETO promiscuously targets and blocks the activities of RXR/RARα and other hematopoietic transcription factors. Different functional domains of the AML1/ETO fusion protein are indicated as follows: the Runt DNA-binding domain (DBD) of the AML1 moiety; a region that shares homology with TAF110 and other related TAF proteins; a heptad repeat of hydrophobic amino acids (HHR); a region that shares homology with Drosophila nervy protein; and a C-terminal region containing 2 nonclassical zinc fingers. Positions of indicated transcription factors relative to AML1/ETO do not reflect regions of interaction with the fusion protein.