Survival from study entry stratified by day 28 biomarker panel. The optimized threshold for the biomarker panel measured at day 28 of GVHD treatment was used to define a high versus low panel result. Patients with a high panel (dashed line, N = 41) were much more likely to die by day 180 compared with patients with a low panel (solid line, N = 63; P < .001).