Colocalization of intracellular ADAMTS13 and MR in iDCs. MR mediates endocytosis of ADAMTS13. iDCs were incubated with ADAMTS13-488 for 45 minutes at 37°C. Subsequently, samples were fixed and labeled for MR (A) or DC-SIGN (B) and analyzed by confocal microscopy. (A) Colocalization of ADAMTS13 (green) with MR (red) was observed (merge). (B) Labeling of DC-SIGN (red) showed no colocalization with ADAMTS13 (green).