Figure 4
Figure 4. Bcl-XL expression and DP apoptosis in PS KO × Bcl-XLflox/+ animals. Thymocytes from PS KO, PS KO × Bcl-XLflox/+, CD4-Cre, or control animals were harvested, protein were extracts collected, and Bcl-XL level was measured by WB (A). Some animals from these same groups were treated intraperitoneally with anti-CD3, thymocytes were harvested 40 hours later, and the percentage of DP or SP thymocytes was measured by FACS (B). Each graphic is representative of 1 animal of 3 evaluated. (B) Value in each quadrant represents the percentage of each cell population inside the thymus.

Bcl-XL expression and DP apoptosis in PS KO × Bcl-XLflox/+ animals. Thymocytes from PS KO, PS KO × Bcl-XLflox/+, CD4-Cre, or control animals were harvested, protein were extracts collected, and Bcl-XL level was measured by WB (A). Some animals from these same groups were treated intraperitoneally with anti-CD3, thymocytes were harvested 40 hours later, and the percentage of DP or SP thymocytes was measured by FACS (B). Each graphic is representative of 1 animal of 3 evaluated. (B) Value in each quadrant represents the percentage of each cell population inside the thymus.

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