mAbTAFI/TM#16 can effectively block baboon TAFI (bTAFI) activation in plasma, shutting off the prolongation of clot lysis. In the presence of 1.5 μM tick anticoagulant peptide (TAP), mAbTAFI/TM#16 was titrated into clots formed with one-third diluted normal baboon plasma (NBP) in the presence (■) and absence (●) of 20 nM thrombomodulin. At mAbTAFI/TM#16 concentrations of 31.3 nM and greater, no bTAFIa-induced prolongation of lysis times was observed.