Figure 1
![Figure 1. mAbTAFI/TM#16 specifically inhibits thrombin-thrombomodulin activation of purified baboon TAFI (bTAFI). (A) In the absence of the mAbTAFI/TM#16, bTAFI is activated by thrombin (IIa) alone, IIa/thrombomodulin (TM)/unfractionated heparin (UH), plasmin (Pn) alone, and Pn/UH, but most effectively by IIa/TM as determined by activity of bTAFIa (inferred from rate of 3-(2-furyl)acryloyl-Ala-Arg-OH [FAAR] hydrolysis). Addition of the mAbTAFI/TM#16 dramatically reduces bTAFIa activity involving TM-associated activation. (B) The same data displayed as percentage inhibition of TAFI activity, illustrating only activation by IIa/TM (± UH) is blocked by the mAbTAFI/TM#16. Data are expressed as mean (± range); n = 2.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/110/9/10.1182_blood-2007-03-078824/7/zh80220708980001.jpeg?Expires=1724221775&Signature=t2XW8mby6BuRvsupl2foqQAuolc3coQExnbWgKghyMIqVt5xDXzVA1NtHgx58HgubpTF~WjJLzC0eA0LrdVwThrSrkDHvbmWoGF6bk5SeYrB2xnzmiY4YhEyVTsryFDnN3CWG-e4sSEGgieJblyeKVbI6lCeQbAoduEgxuTRRtYmTVbnE5kJNZVavzEh-fZmlyjMCXri48kAANZu6ahjfO9GQlNNSoFPWaXxHU2~oUxfFT2aaycqomXLgbnHA0X6CXBM1Zx9Czk6K~0j55sWNbcXXdykygpje86hH~7K8BZzaxwBiAwwlmUXcp8aPdcBRn33fEaQ5bD1fw2uXzcXpg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
mAbTAFI/TM#16 specifically inhibits thrombin-thrombomodulin activation of purified baboon TAFI (bTAFI). (A) In the absence of the mAbTAFI/TM#16, bTAFI is activated by thrombin (IIa) alone, IIa/thrombomodulin (TM)/unfractionated heparin (UH), plasmin (Pn) alone, and Pn/UH, but most effectively by IIa/TM as determined by activity of bTAFIa (inferred from rate of 3-(2-furyl)acryloyl-Ala-Arg-OH [FAAR] hydrolysis). Addition of the mAbTAFI/TM#16 dramatically reduces bTAFIa activity involving TM-associated activation. (B) The same data displayed as percentage inhibition of TAFI activity, illustrating only activation by IIa/TM (± UH) is blocked by the mAbTAFI/TM#16. Data are expressed as mean (± range); n = 2.
