Figure 3
Figure 3. LTCC with bone marrow stromal cells promotes self-renewal activity of Ph+/VE-cadherin+ leukemic cells independent of the Wnt/β-catenin signaling pathway. Clustering analysis of gene expression profiles in Sup-B15 cells after LTCC with S10 or PatX stromal cells. The hierarchical clusters were created with GEASuite software based on the similarity of gene expression. The green color at the farthest left end of the color scale corresponds to the minimal value; the red color at the farthest right end of the color scale corresponds to the maximum value, black corresponds to the average value of expression. BAS2C, HSPCB, ACTB, and GAPDH served as housekeeping gene controls. Analysis of the representative Wnt pathway is shown.

LTCC with bone marrow stromal cells promotes self-renewal activity of Ph+/VE-cadherin+ leukemic cells independent of the Wnt/β-catenin signaling pathway. Clustering analysis of gene expression profiles in Sup-B15 cells after LTCC with S10 or PatX stromal cells. The hierarchical clusters were created with GEASuite software based on the similarity of gene expression. The green color at the farthest left end of the color scale corresponds to the minimal value; the red color at the farthest right end of the color scale corresponds to the maximum value, black corresponds to the average value of expression. BAS2C, HSPCB, ACTB, and GAPDH served as housekeeping gene controls. Analysis of the representative Wnt pathway is shown.

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