A synapse between an antibody-coated target cell and a macrophage effector. In this minimal depiction 4 surface antigen molecules are engaged by 2 IgG antibody molecules. One has docked with an activating FcγR (typically FcγRIIIA), the other with an inhibitory FcγR (FcγRIIB), on the surface of the effector. Three possible major outcomes between the cells are listed. Among major determinants of outcome are the extents of signaling from each FcγR and the prevailing mediator environment. The 3 outcomes are not mutually exclusive, for example, the target cell might die despite extensive antigenic modulation, and the encounter will influence effector modulation by altering the local mediator environment. Much remains to be learned about this type of synapse.