Activation of mTOR and ERK in NPM-ALK–positive ALCL patient samples. Immunohistochemistry of ALCL samples using antibodies against (phospho-) proteins indicated on the left. Representative images from 9 NPM-ALK–positive ALCL (left) and 14 NPM-ALK–negative ALCL (right) patient samples. ALK antibody staining demonstrates expression of NPM-ALK in ALCL cells. JunB antibody staining is shown as minimum and maximum signal intensities of NPM-ALK–positive (left) and NPM-ALK–negative samples (right). See “Immunohistochemistry” for image acquisition information.