Illustration of p53 TAs in lymphocytes. TAs of p53 transactivate or transrepress hundreds of target genes, whose products are depicted according to their main functions. Downstream events fulfill the tumor suppression function with apoptosis, cell-cycle arrest, DNA repair, senescence, or autophagy as consequences. In the diagram, green hyphenated lines with arrows indicate up-regulation of gene expression; and red hyphenated lines, down-regulation of gene expression. For the downstream events, proteins/effectors are grouped according to their major functions and subcellular locations. Up-regulated effectors are marked in bold and depicted in colors representing functional groups, whereas down-regulated effectors are not in bold and are all depicted in blue.