Genes that are expressed similarly to either GATA1 or GATA2 across human hematopoiesis are often bound by that factor in G1ME cells. (A) The expression levels across primary human hematopoietic cell types for the 50 GATA-1 “nearest neighbor” genes from DMAP47 are shown in the heatmap on the left. On the right, a heatmap depicts GATA-1 binding at each gene in G1ME cells, where intensity of green represents tag density at that position relative to the model gene depicted below the heatmap. In the center, gene names highlighted in green have binding sites within this potential regulatory region (−50 kb to +10 kb relative to the TSS) or were assigned a binding site by the nearest TSS (within 50 kb) criteria. (B) Heatmaps of GATA-2 “nearest neighbor” genes showing gene expression in primary human hematopoietic (left) and GATA-2 binding sites in G1ME cells (right) as in panel A.
