Mitochondrial priming regulates clinical response to chemotherapy in multiple myeloma and acute lyphoblastic leukemia (A) Loss of δΨ_m caused by the BMF peptide in myeloma patient samples correlates to %M-protein reduction. (B) Comparison of priming among all primary human cancers and normal tissues. The cancers with clinical follow up were classified as known chemosensitive or known chemoresistant. Cancers classified as typically chemoresistant (Serous borderline n=3, Endometrial n=3 and Renal n=3) or typically chemosensitive (childhood ALL n=17) lacked individual response data. Data shown are mean ± s.d. across all specimens tested. ANOVA was used to demonstrate statistical significance between the different categories with a Tukey's multiple comparison post test. ns - p value > 0.05 and *** p-value <0.001.