Figure 1.
Figure 1. Characteristics of LMP-T products. (A) Immunophenotyping at time of cryopreservation showed a predominance of CD3+ and CD8+ T cells. Monocytes and B cells were not present in the final products. (B) A majority of products demonstrated robust LMP2 activity, and all products had EBV activity, as demonstrated by their response to LCLs in interferon-γ enzyme-linked immunospot assays. (C-D) Number of LMP1 and LMP2 epitopes and HLA alleles recognized by LMP-specific product. Although we were not able to identify a specific LMP1 epitope recognized by most products, a majority of products recognized ≥2 LMP2 epitopes and HLA alleles.

Characteristics of LMP-T products. (A) Immunophenotyping at time of cryopreservation showed a predominance of CD3+ and CD8+ T cells. Monocytes and B cells were not present in the final products. (B) A majority of products demonstrated robust LMP2 activity, and all products had EBV activity, as demonstrated by their response to LCLs in interferon-γ enzyme-linked immunospot assays. (C-D) Number of LMP1 and LMP2 epitopes and HLA alleles recognized by LMP-specific product. Although we were not able to identify a specific LMP1 epitope recognized by most products, a majority of products recognized ≥2 LMP2 epitopes and HLA alleles.

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