Pathological specimens of PEL. Specimens of a cell block from an HIV⁻ elderly patient with PEL stained by hematoxylin and eosin (HE; A), CD3 (B), CD20 (C), EBV-encoded small RNA (EBER; D), multiple myeloma oncogene 1 (MUM-1; E), CD138 (F), and LANA-1 (G) are shown (original magnification ×200). Staining of CD3 and CD20 on immunohistochemistry (IHC) and EBER in situ hybridization are negative, with positive staining for MUM-1, CD138, and LANA-1 on IHC. All images are courtesy of Koichi Oshima, Kurume University, Kurume, Japan.