Summary of plasma pinometostat PK. (A) Mean (SD) plasma pinometostat concentration–time profile after administration of 24, 36, or 54 mg/m² per day with 21-day CIV infusion. Pinometostat concentrations in plasma rose quickly, reaching an apparent steady-state within 4-8 hours postinfusion, followed by a biphasic decline. A pinometostat concentration–time profile for the 80 mg/m² per day group (n = 3) is not displayed, because only a median profile was available. (B) Mean (SD) plasma pinometostat concentration–time profiles after administration of 54 or 90 mg/m² per day with 28-day CIV infusion. (C) Summary of PK data for each treatment cohort.