Postresolution Mφs trigger FoxP3 expression in CD4 T cells. (A) The relative ratios of blood vs peritoneal Tregs was determined 9 days after zymosan injection (0.1 mg) with postresolution resM, moMφs, and moDCs incubated with CD4 T- and Trp-1 peptide (SGHNCGTCRPGWRGAACNQKILTVR) + TGF-β for 5 days and analyzed for the presence of (B) Foxp3 expression and effector T-cell proliferation. Analysis of these Mφ/DC populations revealed a (C) migratory phenotype that was (D) confirmed by injecting PKH26-PCL^green into mice on day 6 post-zymosan (0.1 mg), which also had PKH26-PCL^red injected into their naïve peritoneum to label resMφs. This resulted in infiltrating moMφs and moDCs labeling positively for only PKH26-PCL^green (shown), whereas resMφs were labeled with both PKH26-PCL^red and PKH26-PCL^green (not shown). Data are presented as mean ± SEM for n = 6 mice/group.