Larger gaps predict faster solute transport and decreased platelet activation. (A) Solute transport, as measured by caged fluorescent albumin, is faster, both in the core (circles) and in the shell (triangles), of diYF mice (empty symbols) compared to wild-type (wt) mice (filled symbols) (experimental data are from Stalker et al,⁹ Figure 2). (B) Simulations (empty symbols) predict measured solute transport data, for both the core (circles) and the shell (triangles) of diYF (filled symbols) mice. (C) Simulation of solute release from a wall region under the core predicts that the average concentration at steady state will be lower in both regions in the diYF mice.