Solute transport can be computationally reproduced. The diagram of the geometry used to simulate the solute transport process is shown above each graph. The hemostatic plug is designed as a combination of 2 homogeneous regions, denoted as “core” and “shell,” in which physical characteristics such as packing density and fibrin content are defined by porosity, permeability, and effective diffusivity. The graphs show data (Welsh at al³ ) and simulations of caged fluorescent albumin transport. The vertical axis shows the normalized concentration of fluorescent albumin from experimental data and simulations. Solute transport is faster in the shell than in the core in vivo. These phenomena can be computationally reproduced only by assuming that the core and shell have different packing densities (A) and not otherwise (B).