Determinations for antithrombotic treatment in patients with AAAs. Antithrombotic therapy, including antiplatelet drugs and anticoagulants, should likely be determined on a patient-to-patient basis. To assess whether patients should receive antithrombotic therapy, AAA progression and aortic wall stability should be assessed. With nominal aortic diameter growth, progression, and low wall stresses, antithrombotics should not be considered because the ILT may protect the wall from further harm. However, a destabilized thrombus with rapidly expanding aortic diameter, progression, and increased wall stress may benefit from antithrombotic therapy to prevent additional degradation of the vasculature, further weakening the aorta and resulting in rupture. Blue/thin arrows represent low outward force, whereas red/thick arrows represent high outward force. TAT, thrombin-antithrombin.