Composition of the ILT in humans and mouse models. (A) Representative picture of a 4.6-cm-diameter ILT (42.9 cm²) being removed from a 6-cm diameter aneurysm (79.4 cm²) during an open surgical procedure. (B) Macroscopic view of an ILT demonstrating the luminal, intermediate, and abluminal layers. (C) Ultrasound image of a human AAA with yellow and red dashed lines outlining the area of the aneurysm and thrombus, respectively. (D) A representative suprarenal AAA aorta from a low-density lipoprotein receptor–deficient (Ldlr^−/−) mouse infused with AngII (1000 ng/kg per min) with an (E) in vivo ultrasound image captured at the maximum diameter on a Vevo 2100 (FUJIFILM VisualSonics Inc), where yellow dashed lines represent the area of the aneurysm and red dashed lines outline the extraluminal thrombus. (F) A representative infrarenal AAA aorta from a C57BL/6J mouse treated with topical elastase to induced aneurysm and administration of β3-aminopropionitrile fumarate salt (BAPN) ad libitum via water bottle to induce an ILT.⁴⁵  (G) In vivo ultrasound of the topical elastase/BAPN model at the point of maximal expansion, where yellow dashed lines represent the area of the AAA and the red dashed lines outline the ILT.