The acute phase of inflammatory response is accompanied by rapid (within minutes) influx of neutrophils and monocytes in response to soluble mediators released by tissue resident cells. During resolution, resident macrophages clear apoptotic neutrophils and make iNOS and proresolving cytokines such as interleukin-10 (IL-10) and transforming growth factor-β (TGF-β). Monocyte-derived macrophages (moMφ) and MoDCs persist in the tissue along with MDSCs and lymphocytes long after classical resolution. MoDCs preferentially drive T-cell proliferation and generation of adaptive immunity in the postresolution phase.