Computational modeling studies demonstrating the impact of impaired platelet mass consolidation on solute distribution within a thrombus. (A) A snapshot of the simulation at steady state showing the core and shell regions, as well as the relative concentration of a solute released at a constant rate from a 3-µm patch on the vessel wall beneath the core region (shown in pseudocolor: red is high, blue low concentration). (B-C) Graphs depict relative concentration in the core (B) and shell (C) regions of a solute released at a constant rate from the vessel wall beneath the core region. The core and shell regions were defined by values for porosity, permeability, and effective diffusion coefficient that were chosen based on their ability to fit the transport data for WT and diYF mice shown in Figure 2 (as described in Tomaiuolo et al⁸ ).