The mutational profile of newly diagnosed cHL. The heat map shows individual nonsynonymous somatic mutations detected in ctDNA of newly diagnosed cHL (n = 80). Each row represents a gene, and each column represents a primary tumor. The heat map was manually clustered to emphasize mutational co-occurrence. Mutations are color-coded in red. The number and type of nonsynonymous somatic mutations in any given patients is plotted above the heat map. The horizontal bar graph shows the gene mutation frequency.