Depletion of CD163⁺macrophages induces the elimination of EBER⁺lymphoma cells in humanize mice model. Clodronate liposome (300 μL/mouse) was injected into Akata-infected mice (intraperitoneally). After 5 days, the spleens were collected. EBER was detected by in situ hybridization (upper). Scale bar, 50 μm. CD68/163 was detected by immunohistochemical staining. Scale bar, 20 μm. The effects of clodronate liposome in mice (lower). EBER and CD68/CD163 expression was analyzed in each mouse spleen. -, no EBER or CD68/163-positive cells in 1 microscopic field; +, <10 positive cells; ++, >10 positive cells. **P < .05, Student t test.