Recurring SEs are associated with TF genes in MM cells and normal controls. (A) SEs identified by ROSE in MM, memB, and PB cells. Selected TFs included in panel C are indicated. (B) SE-associated genes are expressed higher than genes associated with TEs. Box and whiskers plots display FPKM for SE- or TE-associated genes. ***P ≤ .001. (C) Heat map of SE-associated TF genes identified by ROSE in at least 6 MM samples. The blue color indicates the presence of an SE that is associated with the indicated TF gene. The 4 identified clusters (I to IV) are indicated.