Effect of cohesin mutational status on OS in MDS. Kaplan-Meier curves for patients with MDS are shown for (A) STAG2 mutant patients and cohesin WT patients and (B) all cohesin mutant patients vs WT cohesin patients. Median OS of MDS patients with a STAG2 mutation was 35 months vs 50 months (P = .17; HR: 1.8 CI [1.1-3.1]), median survival for cohesin mutant MDS cases was inferior to WT MDS cases (34.2 vs 48.2; P = .21), and a significant survival difference was pronounced in patients with MDS who survived for at least 12 months (P = .01).