Characterization of cohesin mutations in patients with myeloid disease. (A) Structure of the cohesin ring. (B) Position and disease subtype for identified cohesin mutations SMC3 (i), STAG2 (ii), and RAD21 (iii). No correlation was found with any structural motif, and no mutational hotspots were identified. (C) Frequency of cohesin family gene mutations in each myeloid malignancy. (D) Distribution of cohesin family gene mutations identified across the patient cohort.