Pon2^−/−mice have an accelerated coagulation. (A) PT, (B) aPTT, and (C) bleeding time of the tail vein of Pon2^−/− and WT mice (n = 16-21). ***P ≤ .0008; **P = .0041; Mann-Whitney U test. (D) Basal plasma levels of active thrombin in Pon2^−/− and WT mice (n = 2-3). *P ≤ .0138; Student t test. (E) Plasma TAT levels in Pon2^−/− and WT mice (n = 2-3). Student t test. (F) PT and (G) aPTT of NAC-treated Pon2^−/− mice compared with Pon2^−/− and WT mice (n = 7-28). ***P < .001; **P < .01; *P < .05; Kruskal-Wallis test with the Dunn multiple comparison test. (H) Coagulation factor activities of Pon2^−/− and WT mice determined by coagulation time measurement in factor-depleted plasma (n = 6-14). **P = .0019; *P ≤ .047; n.s.; Student t test. Scatter plots show results for individual mice, mean and SEM. n.s., not significant.