Pon2 deficiency triggers increased IL-6 and CCL22 release from the vasculature. Plasma concentrations of (A) IL-6 and (B) CCL22 quantified by multianalyte chemiluminescent ELISA array using plasma samples of Pon2^−/− and WT mice (n = 7-8). *P ≤ .0377; Mann-Whitney U test. (C-D) IL-6 and CCL22 plasma concentrations in plasma derived from BM chimeras and transplantation controls (n = 6). Adjusted P values are indicated; Kruskal-Wallis test with the Dunn multiple comparison test. (E) IL-6 concentrations in cell-culture supernatant of ECs isolated from Pon2^−/− and WT quantified as in panels A-D. *P ≤ .0351; Student t test.