Effect of AHR modulation on AML blasts and NK cell function. (A) AHR expression profiles of AML cell lines and primary AML samples were evaluated by flow cytometry. (B-C) Primary human AML samples were either treated with DMSO (vehicle control) or CH223191 for 48 hours, and cell survival by trypan blue counting and apoptosis by annexin V/propidium iodide (PI) flow cytometric evaluation, representative donor, n = 5 primary donors and 4 AML cell lines (*P = .03).