General monitoring recommendations across age groups in TDT.^aBy MRI R2 for liver or MRI T2* for liver and heart with appropriate calibration. LIC and cardiac T2* may be assessed at earlier age (from 6 years) if feasible especially in patients who are on high iron intake. ^bAs assessed by experienced echocardiographer or cardiac MRI. ^cAlanine aminotransferase, aspartate aminotransferase, total and direct bilirubin. ^dThyroid-stimulating hormone; calcium, phosphate, vitamin D, and parathyroid hormone (as indicated); luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol, gonadotropin-releasing hormone (as indicated in cases of abnormal sexual development); fasting blood sugar, oral glucose tolerance test (as indicated). BMD, bone mineral density; ECG, electrocardiogram; LIC, liver iron concentration; LVEF, left-ventricular ejection fraction; Q, every; TE, transient elastography; TRV, tricuspid-regurgitant jet velocity; ULN, upper limit of normal; US, ultrasound.