BMT from Tg-SOX11 donors models lethal MCL. (A) Flow cytometry tracking engraftment of CD45.2 donor bone marrow in the peripheral blood of CD45.1-recipient mice. (B) CD5⁺CD19⁺ cell fraction in splenocytes of sublethally irradiated recipients of bone marrow from Eμ-SOX11-EGFP donors as compared with recipients of bone marrow from WT donors. (C) Pathological analysis of the spleen in recipient mice transplanted with BM from Eμ-SOX11-EGFP donors. (D) Kaplan-Meier survival curves for recipient mice (1st gen) transplanted once with bone marrow from Tg-SOX11 vs WT donors and upon second serial BMT (2nd gen); N = 5/group.